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Research

Vitamin E

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By: Sean Moloughney

Editor, Nutraceuticals World

Indication: Antioxidant status

Source: Am J Clin Nutr, Nov 2003; 78(5):985-92.

Research: A study was undertaken to assess the effect of moderate doses of a combination of vitamin E and caro­tenoids—incorporated into a food product—on markers of antioxidant status and lipid peroxidation in healthy persons. One hundred and five healthy adults were randomly, evenly assigned in this double-blind, placebo-controlled, parallel, 11-week intervention study. After a two-week stabilization period during which the subjects consumed a commercial unfortified spread, the subjects consumed 25 grams per day of the spread containing 43 mg alpha-tocopherol equivalents (alpha-TE; 2-3 fold the U.S. dietary reference intake) and 0.45 mg carotenoids (spread A), 111 mg alpha-TE and 1.24 mg carotenoids (spread B) or 1.3 mg RRR-alpha-tocopherol without carotenoids (spread C).

Results: In subjects consuming spread A, plasma alpha-tocopherol concentrations increased 31%, with small but significant increases in concentrations of alpha-carotene and lutein. This resulted in LDL with significantly higher total antioxidant capacity (17%) and an increased resistance to oxidation, as determined by lag time (18%). Researchers concluded that the consumption of food products containing moderate a­mounts of vitamin E and carotenoids could lead to measurable and significant improvements in antioxidant status and biomarkers of oxidative stress in healthy persons.

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